Defensins

Also known as defensin peptides, alpha-defensin 5, beta-defensin 3, Age-Repair Defensins

What are defensins?

Defensins are small peptides your body releases when skin is wounded. In skincare they signal dormant cells in the hair follicle to build new, younger-acting skin. DefenAge is the brand built around them, and they are an option if retinol irritates your skin.
Best forAging skin Fine lines Large pores Uneven texture

Products with defensins

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Pairs well with

  • Hyaluronic acid
  • Niacinamide
  • Sunscreen
  • Vitamin C

Use with caution

  • Strong acids in the same application

Defensins FAQs

Defensins prompt your skin to make fresh cells. Studies on DefenAge show smaller-looking pores and fewer fine lines after 12 weeks.

Defensins work in a different way and don't cause peeling or sun sensitivity. Retinol has far more research, so many people use both.

Expect to see changes in 6 to 12 weeks with use twice a day.

You can use both. Apply defensins first and retinol after, or use retinol only at night.

Related reading

This content on this page is for general information only and is not medical advice. Always speak to a dermatologist before starting a new skincare routine.