Use once daily. Clean the skin gently with a cleanser such as Toleriane Hydrating Cleanser for normal to dry skin, or Effaclar Purifying Gel for normal to oily skin and pat dry before applying the product. Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation. During the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue use as directed, unless you get irritation that becomes severe. Irritation is more likely to occur in the first few weeks of use or if using more than one topical acne medication at a time but irritation usually lessens with continued use of this product. Applying more than directed will not provide faster or better results. Using a gentle cleanser, like Toleriane Moisturizer, can help offset these side effects. It may take up to 3 months of once daily use to see results. Apply a sunscreen, such as Anthelios Clear Skin, to protect skin against sensitivity to the sun often caused by retinoids. For further instructions, refer to the Drug Facts on the packaging.