PDRN (Polynucleotides)

Also known as salmon DNA, polynucleotides, polydeoxyribonucleotide, sodium DNA

What is PDRN?

PDRN is short for polydeoxyribonucleotide, small DNA fragments usually taken from salmon. In clinics it is injected to help skin heal and rebuild collagen. Serums and creams use it to hydrate, calm, and support repair, and the research on these topical forms is still early.
Best forSkin repair Elasticity Post-procedure care Dehydration

Pairs well with

  • Hyaluronic acid
  • Peptides
  • Niacinamide
  • Sunscreen

Use with caution

  • Fish allergy
  • Expecting injection-level results from a serum

PDRN FAQs

PDRN supports your skin's repair process and holds water. Skin looks calmer, bouncier, and more hydrated.

Most PDRN comes from salmon DNA, which is purified so no fish proteins remain. Some newer products use plant-based versions.

A serum doesn't reach as deep as an injection. It hydrates and soothes the surface, and the deeper rebuilding seen in clinics comes from injected PDRN.

You can use PDRN serums morning and night. They are gentle and layer with most ingredients.

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This content on this page is for general information only and is not medical advice. Always speak to a dermatologist before starting a new skincare routine.