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The Most Effective Face Serums

Serums are among the most effective and expensive product types in skin care, and there are many to choose from; that’s why we have put together a list of the most effective face serums for different skin concerns to keep you from buying the wrong products. Each serum serves a different purpose, designed to treat specific skin concerns and conditions. It is critical to buy the right variety of serum when crafting a personal skin care regimen. The best serum for anti-aging is not often also the best serum for hyperpigmentation. Because it can be so confusing to choose with so many options, we have narrowed down some of our favorite serums for different common skin concerns. In this blog we explain the best anti-aging, anti-bacterial,moisturizing, and skin lightening serums according to dermatologists.

Anti-acne Serums

SkinCeuticals Phytocorrective Gel

SkinCeuticals Phytocorrective gel is the perfect addition to a skin care regimen for oily and sensitive skin types. This serum contains zero oils and zero comedogenic ingredients, and is loaded with antimicrobial, antioxidant ingredients. This product is best for people with recurring acne breakouts as it eliminates acne causing bacteria directly when applied to the skin while not adding any oil to the face. The plant-based ingredients in this product make it great for vegans or others who seek to avoid animal products in their skincare. This phyto corrective gel is versatile, also offering anti-inflammatory and anti-aging properties in addition to its benefits for acne care. On top of all these other benefits, this product is more affordable than most other serums in its category. If you have sensitive, oily skin, this could be the perfect acne treatment serum for your regimen.

La Roche Posay Glycolic Serum

La Roche Posay Glycolic Serum is a strong candidate for treating acne concerns in dry, sensitive skin types. Glycolic acid is effective at eliminating acne causing bacteria on the skin by making the skin too acidic for bacteria to survive. This affordable anti-acne serum is designed specifically for the reduction of clogged pores, the acceleration of natural exfoliation, and for keeping oils on the face of dry skin types. Dry skin types should be careful to avoid products that strip too much oil from the skin. This is because removing too much oil from dry skin can result in damage to the skin barrier. This is a natural serum with very few ingredients, great for people concerned about overly complex formulas in their skin care products. If you have dry skin and acne concerns, this could be the perfect product for your regimen.

Anti-aging Serums

SkinMedica TNS Advanced

One of the most exciting innovations in anti-aging skin care technology is the advancement of peptides in various products. In terms of anti-aging peptide products, SkinMedica TNS Advanced is the top of the line. The peptides used in this product quickly smooth and improve the appearance of fine lines and wrinkles on the face. Using this product regularly can result in improvements to your wrinkles and dry skin in as few as two weeks. TNS Advanced has the added benefit of profound skin hydration, it is full of proven moisturizing ingredients like shea butter and glycerin to leave your face feeling smooth, plump, and shiny without a greasy feeling. If you are concerned about improving wrinkles and dry skin quickly before a big day like a photoshoot, a wedding, or a major corporate gathering, this could be the right serum for you.

Sente Bio Complete Serum

Like SkinMedica TNS Advanced, Sente Bio Complete serum is a great anti-aging serum that targets wrinkles and fine lines on the face. One major benefit of this product is its inclusion of multiple retinoids in its formulation. Retinoids are extremely versatile ingredients that are commonly used for the treatment of wrinkles and acne. Because retinoids can sometimes dry the skin, this product is designed with multiple potent humectant moisturizer ingredients included such as hyaluronic acid and glycerin. These ingredients ensure that the skin is not left dry, itchy, and irritated as it absorbs retinoids. As with any retinoid-based product, we recommend following the application of Sente Bio Complete Serum with a dedicated moisturizer to lock in hydration and prevent peeling. Oily skin types are not at risk of clogged pores or acne breakouts when using this product, as none of the ingredients are comedogenic. If you have the dual concerns of developing wrinkles and frequent acne breakouts, this could be the right serum for your regimen.

SkinCeuticals CE Ferulic

SkinCeuticals CE Ferulic is one of the most proven and recommended serums by dermatologists anywhere. This product is extremely rich in free radical eliminating antioxidants like ferulic acid, Vitamins C and E, which are great for protecting against and repairing sun damage on the skin. The best way to treat wrinkles is to prevent them, so an effective antioxidant serum is crucial for the best skin health. SkinCeuticals CE Ferulic protects against causes of aging such as pollution and radiation. Like many other great anti-aging serums, this product contains humectant moisturizing ingredients like glycerin that keep the skin hydrated while the other ingredients treat sun damage. With zero added oils and no comedogenic properties, this product is often considered among the best serums for antioxidant treatments on acne prone skin. If you spend a lot of time exposed to the sun, you need an antioxidant in your skin care regimen; and if you need an antioxidant, there are few if any products more effective than SkinCeuticals CE Ferulic.

Moisturizing Serums

PCA Hydrating Serum

PCA Hydrating Serum is designed to provide a potent moisturization to the skin through ingredients like Glycerin and Aloe. The main focus of this product is skin hydration, meaning it is great not only for protecting dry skin but for soothing inflammation related to pre-existing dryness. The combination of glycerin and aloe in this ingredient means it is rich in moisturizing humectants that pull moisture to the surface of the skin. Another benefit of this product is that it can help to even out skin tones and prevent dark spots through its active ingredient, Niacinamide. Niacinamide is a PAR-2 blocker, which means it stops the development of dark spots before they have the chance to grow. Overall, this product is best used right after your cleanser, when the most oils are removed from your face, to replenish the essential lipids that make up the skin barrier. If your main skin concern is dryness of the face, this humectant-packed serum is an excellent choice for your regimen.

La Roche Posay Vitamin C Serum

This serum is great for managing moisture on oily skin types, and for binding free radicals that cause wrinkles on the face. As an affordable option, La Roche Posay Vitamin C Serum stands out for its potent hydrating qualities and effective variety of antioxidants. Antioxidants help prevent wrinkles caused by things like pollution and radiation from the sun. La Roche Posay Vitamin C serum also contains Salicylic acid, a fantastic ingredient for oily skin types with acne concerns because it eliminates acne causing bacteria while stripping excess sebum. Salicylic acid even aids in skin exfoliation. As the salicylic acid works to cleanse the skin, moisturizing glycerin pulls moisture from deep within the skin towards the surface, keeping your skin looking fresh. This serum is not designed for dry skin types even though it has moisturizing qualities; rather, it is designed for oily skin types who need a certain level of skin hydration to balance out their use of cleansers. If you have oily skin, acne concerns, but sometimes experience too much dryness on the face after a cleanser, consider La Roche Posay Vitamin C Serum for your regimen.

Replenix Hyaluronic Acid Hydration Serum

Replenix Hyaluronic Acid Hydration Serum is super effective at hydrating the face and keeping it moisturized. This product has a high concentration of hyaluronic acid, one of the best and most researched humectant moisturizers on the market. Like glycerin, hyaluronic acid brings water from deep within the skin towards the surface, resulting in plump, hydrated skin. The fullness of the face following use of this product can temporarily improve the appearance of fine lines and wrinkles, making it a great multifunctional product for your morning skin care regimen. This product also has antioxidant qualities because it contains various tea extracts with known free radical binding benefits. Not only will Replenix Hyaluronic Acid Hydration Serum keep the skin moisturized, but it works to prevent the development of new wrinkles caused by solar radiation or pollution. If you have extremely dry skin and need a proven twice daily moisturizing serum, look no further than Replenix Hyaluronic Acid Hydration Serum.

Skin Lightening Serums

Vichy LiftActiv B3 Serum

Vichy LiftActive B3 Serum is one of the most affordable skin lightening serums on the market, with studied and proven ingredients such as niacinamide and glycolic acid as active ingredients. The main skin lightening ingredient in this product is niacinamide, a PAR-2 blocker that prevents dark spots and treats existing dark spots. Glycolic acid assists in the skin’s natural exfoliation, helping remove pre-existing dark spots at the surface of the skin. Vichy LiftActive B3 Serum is fragrance free, meaning it will not interfere with your perfume or cologne when applied. Glycerin is also present in this product, preventing inflammation or dehydration that can sometimes accompany exfoliating products. Because this product is oil free and moisturizing, it is safe for all skin types to use, but is specifically designed for dry and unevenly pigmented skin types. If you struggle with frequent dark spots and have dry skin, and need an affordable serum for your regimen, this is a wonderful choice.

Biopelle Brightening KNR Serum

Biopelle Brightening KNR Serum is a nighttime serum with retinoids that treats dark spots, wrinkles, and acne all in one product. The main skin lightening ingredients in this product are Kojic acid and Niacinamide. Kojic acid is a tyrosinase inhibitor, meaning it interferes with the production of dark spots within the skin so they never appear in the first place. Tyrosinase inhibitors are the most common type of skin lightening ingredient and have thousands of studies supporting their use in hyperpigmentation treatments. In combination with the PAR-2 blocker, Niacinamide, this serum tackles dark spots from two angles. Since retinoids are present in this formulation, this product should be applied at night as retinoids can irritate the skin when exposed to direct sunlight. Retinoids are extremely common in products designed for wrinkle defense and acne treatment. This product aims to aid in the penetration of retinoids, meaning it helps the retinoids get into the skin to work faster and more efficiently than retinoids alone. Loaded with soothing, anti-inflammatory glycerin, this serum is safe for all skin types, but is best for oily, sensitive, unevenly pigmented skin that’s prone to wrinkles. This is a fantastic all-in-one serum that only needs to be applied once per day before bed. If you have a need for anti-aging, pigment evening, acne treating serum with proven ingredients trusted by dermatologists, consider Biopelle Brightening KNR Serum.


Each serum on the skin care market works slightly differently and targets varying skin concerns from aging skin, dry skin, sensitive skin, to hyperpigmented skin and more. Choosing the right serum for your specific needs and concerns is critical in seeing the kinds of results you are looking for. Not every serum works for every skin type, so choosing based on your skin type makes all the difference. With products as expensive as serums, buying the wrong variety can be devastating to not only your skin health, but your wallet and your trust for skin care products in the future. We hope our recommendations and explanations above give you more confidence before you buy!